The Shoggoth is a kind of slime-monster originating from the Cthulhu Mythos created by H.P. Lovecraft. These are bio-engineered servitors of the Elder Things, created as living, protoplasmic toolsets with the ability to temporarily form any kind of biological tool-equivalent they may need for a specific task, and then reabsorb it back into their gelatinous mass when it became superfluous. Unfortunately for the Elder Things, the shoggoths evolved greater levels of sapience than they had intended or anticipated, resulting in them revolting against their creators.
Monster Hunter International
Shoggoths in Monster Hunter International are the lowest true servant (as opposed to zombies which multiple sources can create and control) of The Old Ones. They are typically sent to aid those bastards crazy enough to worship alien squid things yet are actually relevant to the being's interest. They are highly vulnerable to fire.
Oddly enough, at least one good Shoggoth is shown to have existed.
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As a matter of fact, almost nobody ever thought that "shoggoth" and "monstergirls" should go together. The idea seemed just too weird. Until that crazy bastard Kenkou Cross did one for his Monster Girl Encyclopedia, basically turning the shoggoth into a cute slime-girl maid who uses her bio-toolset abilities to create whatever tools she needs for the job, up to and including shapeshifting into a bed to bang her chosen human master in. Which admittedly makes a lot of sense.